Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

Daniel L. McCartney1,*, Josine L. Min2,3,*, Rebecca C. Richmond2,3*, Ake T. Lu4,*, Maria K. Sobczyk2,3 ,*, Gail Davies5,*, Linda Broer6,†, Xiuqing Guo7,†, Ayoung Jeong8,9†, Jeesun Jung10,†, Silva Kasela11,†, Seyma Katrinli12,†, Pei-Lun Kuo13,†, Pamela R. Matias-Garcia14,15,16,†, Pashupati P. Mishra17,†, Marianne Nygaard18,19,†, Teemu Palviainen20,†, Amit Patki21,†, Laura M. Raffield22,†, Scott M. Ratliff23†, Tom G. Richardson2,3,†, Oliver Robinson24,†, Mette Soerensen18,19,25,†, Dianjianyi Sun26,†, Pei-Chien Tsai27,28,29,†, Matthijs D. van der Zee30,31,†, Xiaochuan Wang32,†, Yunzhang Wang33,†, Rui Xia34,†, Zongli Xu35,†, Jie Yao36,†, Wei Zhao23,†, Adolfo Correa37, Eric Boerwinkle38, Pierre-Antoine Dugué32,39,40, Peter Durda41, Hannah Elliott2,3, Christian Gieger14,15, GoDMC42,, Eco J.C. de Geus30,31, Sarah E. Harris5, Gibran Hemani2,3, Medea Imboden8,9, Mika Kähönen43, Sharon L.R. Kardia23, Jacob K. Kresovich35, Shengxu Li44, Kathryn L. Lunetta45, Massimo Mangino27,46, Dan Mason47, Andrew M. McIntosh48, Jonas Mengel-From18,19, Ann Zenobia Moore13, Joanne M. Murabito49, Miina Ollikainen20, Jim Pankow50, Nancy L. Pedersen33, Annette Peters15,51, Silvia Polidoro24, David J. Porteous1, Olli Raitakari52,53,54, Stephen S. Rich55, Dale P. Sandler35, Elina Sillanpää20,56, Alicia K Smith12,57, Melissa C. Southey32,39,40, Konstantin Strauch58,59,60, Hemant Tiwari21, Toshiko Tanaka13, Therese Tillin61, Andre G Uitterlinden6,62, David J. Van Den Berg63, Jenny van Dongen30,31, James G. Wilson64,65, John Wright47, Idil Yet27,66, Donna Arnett67, Stefania Bandinelli68, Jordana T. Bell27, Alexandra M Binder69,70, Dorret I Boomsma30,31, Wei Chen71, Kaare Christensen18,19,25, Karen N. Conneely72, Paul Elliott24, Luigi Ferrucci13, Myriam Fornage34, Sara Hägg33, Caroline Hayward73, Marguerite Irvin74, Jaakko Kaprio20,75, Deborah A. Lawlor2,3,76, Terho Lehtimäki17, Falk W. Lohoff10, Lili Milani11, Roger L. Milne32,39,40, Nicole Probst-Hensch8,9, Alex P. Reiner77, Beate Ritz69, Jerome I. Rotter7, Jennifer A. Smith23, Jack A. Taylor35, Joyce B.J. van Meurs6,62, Paolo Vineis24, Melanie Waldenberger14,15,51, Ian J. Deary5, Caroline L. Relton2,3, Steve Horvath, Riccardo E. Marioni