Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
| Submitting Author |
Weinstock, Joshua
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|---|---|
| Submitting Author's Email | |
| Authors |
Joshua S. Weinstock1, JK Gopakumar2, Bala Bharathi Burugula3, Md Mesbah Uddin4, Cecelia A. Laurie5, Jai G. Broome5,6, Kent D. Taylor7, Xiuqing Guo7, Moritz F. Sinner8,9, Aenne S. von Falkenhausen8,9, Stefan Kääb8,9, Alan R. Shuldiner10, Jeffrey R. O'Connell10, Joshua P. Lewis10, Eric Boerwinkle11, Kathleen C. Barnes12, Nathalie Chami13,14, Eimear E. Kenny15, Ruth J.. Loos13,14, Myriam Fornage16, Lifang Hou17, Donald M. Lloyd-Jones17, Susan Redline18,19, Brian E. Cade18,19,4, Bruce M. Psaty20,21,22, Joshua C. Bis20, Jennifer A. Brody20, Edwin K. Silverman23, Jeong H. Yun23, Dandi Qiao23, Nicholette D. Palmer24, Barry I. Freedman25, Donald W. Bowden24, Michael H. Cho26, Dawn L. DeMeo26, Ramachandran S. Vasan27, Andrew D. Johnson28, Rasika A. Mathias29, Lisa R. Yanek29, Lewis C. Becker29, Sharon Kardia30, Jiang He31, Michiel Rienstra32, Pim Van der Harst32, Robert Kaplan33, Susan R. Heckbert34,35, Nicholas L. Smith34,35,36, Kerri L. Wiggins37, Donna K. Arnett38, Marguerite R. Irvin39, Hemant Tiwari39, Michael J. Cutler40, Stacey Knight40, J Brent. Muhlestein40, Adolfo Correa41, Laura M. Raffield42, Yan Gao43, Mariza de Andrade44, Jerome I. Rotter7, Stephen S. Rich45, Ani W. Manichaikul45, Barbara A. Konkle46, Jill M. Johnsen47,46, Marsha M. Wheeler48, J. Gustav Smith49,50,51, Olle Melander52, Peter M. Nilsson52, Brian S. Custer53, Ravindranath Duggirala54,55, Joanne E. Curran54,55, John Blangero54,55, Stephen McGarvey56, C. Charles. Gu57, Yii-Der Ida. Chen58, Wen-Jane Lee59, Gregory M. Marcus60, John P. Kane61, Clive R. Pullinger62, M. Benjamin Shoemaker63, Dawood Darbar64, Dan Roden65, Christine Albert66, Charles Kooperberg67, Ying Zhou67, Pinkal Desai68,69, Andrew Johnson28,70, Rasika Mathias29, Thomas W. Blackwell1, Goncalo R. Abecasis1,71, Albert V. Smith1, Hyun M. Kang1, Pradeep Natarajan72,4,73, Jacob Kitzman3, Alexander P. Reiner67,74, Alexander G. Bick75, Sidd Jaiswal2
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| Journal name for most current submission |
Nature
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| Associated TOPMed paper proposal | |
| This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" |
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
|
| Acknowledgments |
I have followed instructions for TOPMed Acknowledgments
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| I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. |
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
|
| I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. |
Yes
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| I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. |
Yes
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| I certify that all co-authors have reviewed and approved the manuscript for submission. |
Yes
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| Upload all necessary study-specific approval documentation. | |
| I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
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| I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient. |
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
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| I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
|
TOPMed data used in this manuscript
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| Parent Study: Consent Group | Review Status |
|---|---|
| AFLMU:HMB-IRB-PUB-COL-NPU-MDS | Approved |
| ARIC:DS-CVD-IRB | Approved automatically after 2 weeks |
| ARIC:HMB-IRB | Approved automatically after 2 weeks |
| Amish:HMB-IRB-MDS | Approved |
| AustralianFamilialAF:HMB-NPU-MDS | Approved |
| BAGS:GRU-IRB | Approved |
| BioMe:HMB-NPU | Approved |
| BioVU_AF:HMB-GSO | Approved automatically after 2 weeks |
| CARDIA:HMB-IRB | Approved automatically after 2 weeks |
| CARDIA:HMB-IRB-NPU | Approved automatically after 2 weeks |
| CATHGEN:DS-CVD-IRB | Approved automatically after 2 weeks |
| CCAF:GRU-IRB | Approved automatically after 2 weeks |
| CFS:DS-HLBS-IRB-NPU | Approved automatically after 2 weeks |
| CHS:DS-CVD-MDS | Approved |
| CHS:DS-CVD-NPU-MDS | Approved |
| CHS:HMB-MDS | Approved |
| CHS:HMB-NPU-MDS | Approved |
| COPDGene:DS-CS-RD | Approved |
| COPDGene:HMB | Approved |
| DECAF:GRU | Approved |
| DHS:DS-DHD-IRB-COL-NPU | Approved |
| DHS:HMB-IRB-COL-NPU | Approved |
| ECLIPSE:DS-CS-MDS-RD | Approved |
| EGCUT:GRU | Approved automatically after 2 weeks |
| EOCOPD:DS-CS-RD | Approved |
| FHS:HMB-IRB-MDS | Approved automatically after 2 weeks |
| FHS:HMB-IRB-NPU-MDS | Approved automatically after 2 weeks |
| GENAF:HMB-NPU | Disapproved |
| GENOA:DS-ASC-RF-NPU | Approved |
| GGAF:GRU | Approved |
| GOLDN:DS-CVD-IRB | Approved |
| GenSalt:DS-HCR-IRB | Approved automatically after 2 weeks |
| GeneSTAR:DS-CVD-IRB-NPU-MDS | Approved |
| HCHS_SOL:HMB | Approved automatically after 2 weeks |
| HCHS_SOL:HMB-NPU | Approved automatically after 2 weeks |
| HVH:DS-CVD-IRB-MDS | Approved automatically after 2 weeks |
| HVH:HMB-IRB-MDS | Approved automatically after 2 weeks |
| HyperGEN:DS-CVD-IRB-RD | Approved |
| HyperGEN:GRU-IRB | Approved |
| INSPIRE_AF:DS-MULTIPLE_DISEASES-MDS | Approved |
| JHS:DS-FDO-IRB | Approved |
| JHS:DS-FDO-IRB-NPU | Approved |
| JHS:HMB-IRB | Approved |
| JHS:HMB-IRB-NPU | Approved |
| JHU_AF:HMB-NPU-MDS | Approved automatically after 2 weeks |
| MESA:HMB | Approved |
| MESA:HMB-NPU | Approved |
| MGH_AF:DS-AF-IRB-RD | Approved automatically after 2 weeks |
| MGH_AF:HMB-IRB | Approved automatically after 2 weeks |
| MLOF:HMB-PUB | Approved |
| MPP:HMB-NPU-MDS | Approved |
| Mayo_VTE:GRU | Approved |
| PMBB_AF:HMB-IRB-PUB | Approved automatically after 2 weeks |
| Partners:HMB | Approved automatically after 2 weeks |
| REDS-III_Brazil:GRU-IRB-PUB-COL-NPU | Approved automatically after 2 weeks |
| SAFS:DS-DHD-IRB-PUB-MDS-RD | Approved |
| SAPPHIRE_asthma:HMB-COL | Approved |
| Samoan:GRU-IRB-PUB-COL-NPU-GSO | Approved |
| THRV:DS-CVD-IRB-COL-NPU-RD | Approved automatically after 2 weeks |
| UCSF_AF:DS-ASC-RD-MDS | Approved |
| VAFAR:HMB-IRB | Approved automatically after 2 weeks |
| VU_AF:GRU-IRB | Approved |
| WGHS:HMB | Approved automatically after 2 weeks |
| WHI:HMB-IRB | Approved |
| WHI:HMB-IRB-NPU | Approved |
| miRhythm:GRU | Approved automatically after 2 weeks |
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