Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes
| Submitting Author |
Peloso, Gina
|
|---|---|
| Submitting Author's Email | |
| Authors |
George Hindy1-3, Peter Dornbos4-6, Mark D. Chaffin2,7,8, Dajiang J. Liu9, Minxian X. Wang2,7,10, Carlos A. Aguilar-Salinas11, Lucinda Antonacci-Fulton12,13, Diego Ardissino14-16, Donna K. Arnett17, Stella Aslibekyan18, Gil Atzmon19,20, Christie M. Ballantyne21,22, Francisco Barajas-Olmos23, Nir Barzilai19, Lewis C. Becker24, Lawrence F. Bielak25, Joshua C. Bis26, John Blangero27, Eric Boerwinkle28,29, Lori L. Bonnycastle30, Erwin Bottinger31,32, Donald W. Bowden33, Matthew J. Bown34,35, Jennifer A. Brody26, Jai G. Broome36, Noël P. Burtt4, Brian E. Cade37,38, Federico Centeno-Cruz23, Edmund Chan39, Yi-Cheng Chang40, Yii-Der I. Chen41, Ching-Yu Cheng42-44, Won Jung Choi45, Rajiv Chowdhury46,47, Cecilia Contreras-Cubas23, Emilio J. Córdova23, Adolfo Correa48, L Adrienne Cupples49,50, Joanne E. Curran27, John Danesh46,51, Paul S. de Vries28, Ralph A. DeFronzo52, Harsha Doddapaneni29, Ravindranath Duggirala27, Susan K. Dutcher12,13, Patrick T. Ellinor8,10, Leslie S. Emery36, Jose C. Florez2,7,53,54, Myriam Fornage55, Barry I. Freedman56, Valentin Fuster57,58, Ma. Eugenia Garay-Sevilla59, Humberto García-Ortiz23, Soren Germer60, Richard A. Gibbs29,61, Christian Gieger62-64, Benjamin Glaser65, Clicerio Gonzalez66, Maria Elena Gonzalez-Villalpando67, Mariaelisa Graff68, Niels Grarup69, Leif C. Groop70,71, Xiuqing Guo41, Namrata Gupta2, Sohee Han72, Craig L. Hanis73, Torben Hansen69,74, Jiang He75,76, Nancy L. Heard-Costa50,77, Yi-Jen Hung78, Mi Yeong Hwang72, Marguerite R. Irvin79, Sergio Islas-Andrade80, Gail P. Jarvik81, Hyun Min Kang82, Sharon L.R. Kardia25, Tanika Kelly75, Eimear E. Kenny57,83,84, Alyna T. Khan36, Bong-Jo Kim72, Ryan W. Kim45, Young Jin Kim72, Heikki A. Koistinen85-87, Charles Kooperberg88, Johanna Kuusisto89, Soo Heon Kwak90, Markku Laakso89, Leslie A. Lange91, Jiwon Lee37, Juyoung Lee72, Seonwook Lee45, Donna M. Lehman52, Rozenn N. Lemaitre26, Allan Linneberg92,93, Jianjun Liu39,94, Ruth J.F. Loos95,96, Steven A. Lubitz8,10, Valeriya Lyssenko70,97, Ronald C.W. Ma98-100, Lisa Warsinger Martin101, Angélica Martínez-Hernández23, Rasika A. Mathias24, Stephen T. McGarvey102, Ruth McPherson103, James B. Meigs54,104,105, Thomas Meitinger106,107, Olle Melander70,108, Elvia Mendoza-Caamal23, Ginger A. Metcalf29, Xuenan Mi75, Karen L. Mohlke109, May E. Montasser110, Jee-Young Moon111, Hortensia Moreno-Macías112, Alanna C. Morrison28, Donna M. Muzny29, Sarah C. Nelson36, Peter M. Nilsson3, Jeffrey R. O'Connell110, Marju Orho-Melander3, Lorena Orozco23, Colin N.A. Palmer113, Nicholette D. Palmer33, Cheol Joo Park45, Kyong Soo Park90,114,115, Oluf Pedersen69, Juan M. Peralta27, Patricia A. Peyser25, Wendy S. Post116, Michael Preuss95, Bruce M. Psaty26,117,118, Qibin Qi111, DC Rao119, Susan Redline37,38, Alexander P. Reiner120, Cristina Revilla-Monsalve121, Stephen S. Rich122, Nilesh Samani34,35, Heribert Schunkert123, Claudia Schurmann31,32,95, Daekwan Seo45, Jeong-Sun Seo45, Xueling Sim124, Rob Sladek125-127, Kerrin S. Small128, Wing Yee So98-100, Adrienne M. Stilp36, E Shyong Tai39,124,129, Claudia H.T. Tam98-100, Kent D. Taylor41, Yik Ying Teo124,130,131, Farook Thameem132, Brian Tomlinson133, Michael Y. Tsai134, Tiinamaija Tuomi135-137, Jaakko Tuomilehto138-140, Teresa Tusié-Luna11,141, Rob M. van Dam124,142, Ramachandran S. Vasan50,143, Karine A. Viaud Martinez144, Fei Fei Wang36, Xuzhi Wang49, Hugh Watkins145, Daniel E. Weeks146,147, James G. Wilson148, Tien-Yin Wong42-44, Lisa R. Yanek24, AMP-T2D-GENES, Myocardial Infarction Genetics Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, NHLBI TOPMed Lipids Working Group, Sekar Kathiresan2,7,54,149, Jerome I. Rotter41, Michael Boehnke82, Mark I. McCarthy150,151, Cristen J. Willer152-154, Pradeep Natarajan2,8,10,54, Jason A. Flannick4-6, Amit V. Khera2,7,8, Gina M. Peloso49
|
| Journal name for most current submission |
Cell Genomics
|
| Associated TOPMed paper proposal | |
| This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" |
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
|
| Acknowledgments |
I have followed instructions for TOPMed Acknowledgments
|
| I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. |
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
|
| I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. |
Yes
|
| I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. |
Yes
|
| I certify that all co-authors have reviewed and approved the manuscript for submission. |
Yes
|
| Upload all necessary study-specific approval documentation. | |
| I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
|
| I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient. |
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
|
| I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
|
TOPMed data used in this manuscript
The data set approvals listed here should match the TOPMed data used in this manuscript.
Don't see all the data sets you need? Request more data sets at any time.
Please "cancel" any data set requests that were not used in this manuscript. Note: only the paper proposal submitter or their designated updater can cancel data sets.
| Parent Study: Consent Group | Review Status |
|---|---|
| ARIC:DS-CVD-IRB | Approved automatically after 2 weeks |
| ARIC:HMB-IRB | Approved automatically after 2 weeks |
| Amish:HMB-IRB-MDS | Approved |
| BioMe:GRU | Request cancelled by original requester |
| BioMe:HMB-NPU | Approved |
| CARDIA:HMB-IRB | Approved automatically after 2 weeks |
| CARDIA:HMB-IRB-NPU | Approved automatically after 2 weeks |
| CFS:DS-HLBS-IRB-NPU | Approved |
| CHS:HMB-NPU-MDS | Approved |
| DHS:DS-DHD-IRB-COL-NPU | Approved automatically after 2 weeks |
| DHS:HMB-IRB-COL-NPU | Approved automatically after 2 weeks |
| FHS:HMB-IRB-MDS | Approved automatically after 2 weeks |
| FHS:HMB-IRB-NPU-MDS | Approved |
| GENOA:DS-ASC-RF-NPU | Approved |
| GOLDN:DS-CVD-IRB | Approved |
| GenSalt:GRU-IRB | Approved automatically after 2 weeks |
| GeneSTAR:DS-CVD-IRB-NPU-MDS | Approved |
| HCHS_SOL:HMB | Approved automatically after 2 weeks |
| HCHS_SOL:HMB-NPU | Approved automatically after 2 weeks |
| HyperGEN:DS-CVD-IRB-RD | Approved |
| HyperGEN:GRU-IRB | Approved |
| JHS:DS-FDO-IRB | Approved |
| JHS:DS-FDO-IRB-NPU | Approved |
| JHS:HMB-IRB | Approved |
| JHS:HMB-IRB-NPU | Approved |
| MESA:HMB | Approved |
| MESA:HMB-NPU | Approved |
| MGH_AF:DS-AF-IRB-RD | Approved |
| MGH_AF:HMB-IRB | Approved |
| Partners:HMB | Request cancelled by original requester |
| SAFS:DS-DHD-IRB-PUB-MDS-RD | Approved |
| Samoan:GRU-IRB-PUB-COL-NPU-GSO | Approved |
| THRV:DS-CVD-IRB-COL-NPU-RD | Approved automatically after 2 weeks |
| WGHS:HMB | Request cancelled by original requester |
| WHI:HMB-IRB | Approved |
| WHI:HMB-IRB-NPU | Approved |
Back to top
