TOPMed WGS and Omics Summary of Approved Projects

TOPMed WGS and Omics Summary of Approved Data
Short Name	Study/Cohort Name	Populations	dbGaP ID	WGS	RNA-seq	Methylation	Metabolomics	Proteomics
AA_CAC	African American Coronary Artery Calcification project	African American families	phs002194	1,159
AFGen	Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval - Atrial Fibrillation Genetics Consortium	European ancestry	AFGen dbGaP IDs	12,742
Africa6K	Integrative Genomic Studies of Heart and Blood Related Traits in Africans	African ancestry	phs002194	6,392	2,934
Amish	Genetics of Cardiometabolic Health in the Amish	Old Order Amish large extended pedigrees	phs000956	1,120
ARIC+VTE	Venous Thromboembolism project	African American (20%)	phs001211 phs001402 phs000993	10,531	6,111	16,524	16,524
ATGC	Asthma Translational Genomics Collaborative	African American, Mexican, and Puerto Rican individuals	ATGC dbGaP IDs	16,494	9,290
BAGS	Barbados Asthma Genetics Study	Barbados families of African descent with >40% of asthmatic members	phs001143	1,085
BCC-PREG	The Boston-Colombia Collaborative for Adverse Pregnancy Outcomes	White, Black, Asian, Hispanic, White Hispanic, AfroCarribean, Ameridians, Mixed	Please see this TOPMed Project's Parent Studies.	14,615
BioMe	Mount Sinai BioMe Biobank	African American (24%), Hispanic/Latino (35%), European (32%), Other (10%)	phs001644	11,626
Boston-Brazil_SCD	Boston-Brazil Collaborative Study of Sickle Cell Disease	Brazilian	phs001599	415
CARDIA	Whole Genome Sequence Analysis in Early Cerebral Small Vessel Disease	African American and Caucasian young adults	phs001612	3,472	6,000	9,480	12,000	12,000
CFS	Cleveland Family Study	African American	phs000954	1,300
CHS	Cardiovascular Health Study	Adults in the USA aged 65 and older	phs001368	4,780
COPDGene	Genetic Epidemiology of COPD	Non-Hispanic White and African-American, current and former smokers with and without COPD (>10,000)	phs000951 phs000946	10,829	800	11,843	8,353
COPDMet	Plasma and BALF Metabolomics in COPDGene and SPIROMICS	Current, former, and never smokers	Please see this TOPMed Project's Parent Studies.
CRA_CAMP	The Genetic Epidemiology of Asthma in Costa Rica and the Childhood Asthma Management Program	Hispanic population with asthma prevalence at 24%	phs001726 phs000988	6,647		3,000	3,000
DS_CHD	Down Syndrome Associated Atrioventricular Septal Defects: New Omic Resources	Parent-Offspring Trios	Please see this TOPMed Project's Parent Studies.	469
ECLIPSE	Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints	Adults aged 40-75 with at least 10 pack-years of smoking	phs001472	2,355
FHS	Framingham Heart Study	European ancestry
GEM-OSA	Genetics, Epigenetics and Metabolomics of OSA subtypes	Canada and United States	Please see this TOPMed Project's Parent Studies.	3,000		3,000	3,000
GeneSTAR	Genetic Studies of Atherosclerosis Risk	African American families, European families	phs001218	1,780
GenSalt	Genetic Epidemiology Network of Salt Sensitivity	Rural Chinese families	phs001217	1,858
GOLDN	Genetics of Lipid Lowering Drugs and Diet Network	European families	phs001359	965
HCHS_SOL	Hispanic Community Health Study - Study of Latinos	Latinos with ancestry from Cuba, Dominican Republic, Mexico, Puerto Rico, Central and South Americas	phs001395	7,834	7,733	13,000	12,226
HIPS	Hemophilia Inhibitor PUPs study	Individuals with severe hemophilia A and weight >3.5 kg	phs002302	25	2,596
HLKSCD	Genetic Variation of Heart, Lung, and Kidney Disease in Sickle Cell Disease: Pre- and Post-Curative Therapies	Adults and children from three SCD centers		1,780
HyperGEN_GENOA	Hypertension Genetic Epidemiology Network and Genetic Epidemiology Network of Arteriopathy	African American families	phs001345 phs001293	3,153
IPF	Whole Genome Sequencing in Familial and Sporadic Idiopathic Pulmonary Fibrosis	European ancestry	phs001607	2,883	835
JHS	Jackson Heart Study	African American, mixed family and population based	phs000964	3,418		1,659	5,266	5,266
LTRC	Lung Tissue Research Consortium	Individuals with lung disease	phs001662	1,541	1,548	3,041	1,548	1,548
MDS	Genomics of Myelodysplastic Syndromes	Adults aged 18 or older	phs002360	473	145
MESA	Multi-Ethnic Study of Atherosclerosis	Multi-ethnic populations	phs001416	7,107	8,903	13,286	12,800	14,200
MLOF	My Life, Our Future: Genotyping for Progress in Hemophilia	Adults and children with hemophilia A	phs001515	5,670	4,500
MWCCS	MACS/WIHS COMBINED COHORT STUDY
nuMoM2b-HHS	nuMoM2b-Heart Health Study	Hispanic (17%), non-Hispanic Black (14%), Asian (4%), other (5%), non-Hispanic White (60%)		4,341	600
OMG_SCD	Outcome Modifying Genes in Sickle Cell Disease	Adults from North Carolina and Georgia	phs001608	653
PCGC_CHD	Pediatric Cardiac Genomics Consortium's Congenital Heart Disease Biobank	Children and adults	phs001735	3,888
PGX_Asthma	Pharmacogenomics of Bronchodilator Response in Minority Children with Asthma	African American, Puerto Rican, and Mexican ancestry	phs001682	423
PharmHU	The Pharmacogenomics of Hydroxyurea in Sickle Cell Disease	Pediatric patients	phs001466	862	826
PROMIS	Pakistan Risk of Myocardial Infarction Study	South Asian ancestry from Pakistan	phs001569	9,204
PUSH_SCD	Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease	Individuals aged 3-20 years	phs001682	423
PVDOMICS	Pulmonary Vascular Disease Omics Analyses	Adults aged 18 or older	phs002358	1,137	4,388	1,800
REDS-III_Brazil	Recipient Epidemiology and Donor Evaluation Study-III	Brazilian	phs001468	2,746
SAFS	San Antonio Family Studies	Mexican American in SAFHS extended pedigrees	phs001215	1,819
Samoan	Samoan Adiposity Study	Samoan	phs000972	1,295
Sarcoidosis	Genetics of Sarcoidosis in African Americans	African American families	phs001207	1,330
SARP	Severe Asthma Research Program	African American (29%), Hispanic (4%), non-Hispanic whites (60%), other (7%)	phs001446	1,890
SCVI	Stanford Cardiovascular Institute iPSC Biobank Study	African American, Asian, Hispanic, and Caucasian	phs002338	1,163	82
SIT_SCD	Silent Infarction Transfusion (SIT) Sickle Cell Disease (SCD)
SPIROMICS	SubPopulations and InteRmediate Outcome Measures In COPD Study	Adults aged 40-80 years at baseline	phs001927	2,711	3,980		3,417
THRV	Taiwan Study of Hypertension using Rare Variants	Taiwan Chinese families		2,170
TOPCHeF	Trans-Omics for Precision Medicine for Congestive Heart Failure	Multi-ancestry	phs002038	839	776
UNID_CM	The Genetic Causes of Unexplained Cardiomyopathies	All ages, newborn to adults		779
walk_PHaSST	Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy	Individuals aged 12-70 years	phs001514	437
WHI	Women's Health Initiative	Women aged 50-79 years	phs001237	11,310	2,365	4,400	4,400	1,000
				196,938	64,412	81,033	82,534	34,014