Please follow this Procedure for Renewal and contact NHLBITOPMeddbGaP@nhlbi.nih.gov with any questions.

TOPMed Projects are a collection of one or more parent studies. Some are derived from a single parent study by selecting a subset of subjects according to various criteria – e.g. relatedness, phenotypes of interest or extent of phenotypic characterization. Some consist of a consortium of multiple parent studies that each contribute subjects with a common phenotype of interest – e.g. atrial fibrillation cases from each of several studies, along with controls from the same or other studies.

The following files are required for submission. The webpages referenced below refer to sections from the dbGaP Study Submission Guide which include information on file formats, minimally required variables by file, and much, much more.

Please work with institutional officials, NHLBI GPAs, and Program Officers to initiate TOPMed dbGaP registration paperwork.

Please use SUBJECT_IDs used by studies within previously submitted dbGaP files for phenotype files requested by Working Groups. Please do not use NWD_IDs within phenotype files due to ongoing genotype QC efforts as sample swaps and other sample identity issues are identified. Phenotype files should be indexed by SUBJECT_ID while VCFs and other sequencing data are indexed by NWD_ID (SAMPLE_ID submitted to dbGaP). This way both file types remain robust to QC issues that arise.