Projects & Studies

Filter the Project and Parent Study tables below to display types of sequencing or start phase.

Parent studies are studies that were selected for inclusion in TOPMed to have their samples sequenced. Parent studies may be:

Cohort studies 

• Framingham Heart Study (FHS)
• Jackson Heart Study (JHS) 
• Atherosclerosis Risk in Communities (ARIC) 
• Cardiovascular Health Study (CHS) 
• Coronary Artery Risk Development in Young Adults Study (CARDIA) 
• Multi-Ethnic Study of Atherosclerosis (MESA) 

Other studies

• Case-control (i.e., Chronic Obstructive Pulmonary Disease Gene Study (COPDGene))
• Randomized trial (i.e., Women’s Health Initiative (WHI))
• Family-based, (i.e., Genetic Epidemiology of Asthma in Costa Rica (CRA))
• Case-only (i.e., Genes-environments and Admixture in Latino Asthmatics (GALAII) and Study of African Americans, Asthma, Genes and Environments (SAGE) studies)
• Other designs

Projects are a collection of one or more parent studies. Some are derived from a single parent study by selecting a subset of subjects according to various criteria (e.g., relatedness, phenotypes of interest or extent of phenotypic characterization). Some consist of a consortium of investigators from multiple parent studies that each contribute subjects with a common phenotype of interest (e.g., atrial fibrillation cases from each of several studies, along with controls from the same or other studies.)

Funded Programs are projects funded by TOPMed/NIH through various funding mechanisms (U01, R01, and others).