A System for Phenotype Harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

Submitting Author	Stilp, Adrienne
Submitting Author's Email	amstilp@uw.edu
Authors	Stilp, Adrienne M Emery, Leslie S Broome, Jai G Buth, Erin J Khan, Alyna T Laurie, Cecelia A Wang, Fei Fei Wong, Quenna Chen, Dongquan D'Augustine, Catherine M Heard-Costa, Nancy L Hohensee, Chancellor R Johnson, William Craig Juarez, Lucia D Liu, Jingmin Mutalik, Karen M Raffield, Laura M Wiggins, Kerri L de Vries, Paul S Kelly, Tanika N Kooperberg, Charles Natarajan, Pradeep Peloso, Gina M Peyser, Patricia A Reiner, Alex P Arnett, Donna K Aslibekyan, Stella Barnes, Kathleen C Bielak, Lawrence F Bis, Joshua C Cade, Brian E Chen, Ming-Huei Correa, Adolfo Cupples, L. Adrienne de Andrade, Mariza Ellinor, Patrick T Fornage, Myriam Franceschini, Nora Gan, Weiniu Ganesh, Santhi K Graffelman, Jan Grove, Megan L Guo, Xiuqing Hawley, Nicola L Hsu, Wan-Ling Jackson, Rebecca D Jaquish, Cashell E Johnson, Andrew D Kardia, Sharon LR Kelly, Shannon Lee, Jiwon Mathias, Rasika A McGarvey, Stephen T Mitchell, Braxton D Montasser, May E Morrison, Alanna C North, Kari E Nouraie, Seyed Mehdi Oelsner, Elizabeth C Pankratz, Nathan Rich, Stephen S Rotter, Jerome I Smith, Jennifer A Taylor, Kent D Vasan, Ramachandran S Weeks, Daniel E Weiss, Scott T Wilson, Carla G Yanek, Lisa R Psaty, Bruce M Heckbert, Susan R Laurie, Cathy C
Journal name for most current submission	American Journal of Epidemiology
Associated TOPMed paper proposal	Phenotype Harmonization of Retrospectively-collected Data in the NHLBI Trans-Omics for Precision Medicine (TOPMed) program
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"	This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
Acknowledgments	I have followed instructions for TOPMed Acknowledgments
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.	I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable.	Yes
I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented.	Yes
I certify that all co-authors have reviewed and approved the manuscript for submission.	Yes
Upload all necessary study-specific approval documentation.	Amish study approval ARIC study approval CARDIA study approval CHS study approval FHS - documentation of no response within 2 weeks GENOA study approval - co-author initials HCHS SOL study approval JHS study approval MESA study approval Samoan study approval WHI study approval
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.	I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.	I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.	I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.

Parent Study: Consent Group	Review Status
ARIC:DS-CVD-IRB	Approved automatically after 2 weeks
ARIC:HMB-IRB	Approved automatically after 2 weeks
Amish:HMB-IRB-MDS	Approved automatically after 2 weeks
CARDIA:HMB-IRB	Approved automatically after 2 weeks
CARDIA:HMB-IRB-NPU	Approved automatically after 2 weeks
CFS:DS-HLBS-IRB-NPU	Approved automatically after 2 weeks
CHS:DS-CVD-MDS	Approved
CHS:DS-CVD-NPU-MDS	Approved
CHS:HMB-MDS	Approved
CHS:HMB-NPU-MDS	Approved
COPDGene:DS-CS-RD	Approved
COPDGene:HMB	Approved
CRA:DS-ASTHMA-IRB-MDS-RD	Approved
FHS:HMB-IRB-MDS	Approved automatically after 2 weeks
FHS:HMB-IRB-NPU-MDS	Approved automatically after 2 weeks
GENOA:DS-ASC-RF-NPU	Approved
GOLDN:DS-CVD-IRB	Approved
HCHS_SOL:HMB	Approved automatically after 2 weeks
HCHS_SOL:HMB-NPU	Approved automatically after 2 weeks
HVH:DS-CVD-IRB-MDS	Approved automatically after 2 weeks
HVH:HMB-IRB-MDS	Approved automatically after 2 weeks
JHS:DS-FDO-IRB	Approved
JHS:DS-FDO-IRB-NPU	Approved
JHS:HMB-IRB	Approved
JHS:HMB-IRB-NPU	Approved
MESA:HMB	Approved
MESA:HMB-NPU	Approved
Mayo_VTE:GRU	Approved
Samoan:GRU-IRB-PUB-COL-NPU-GSO	Approved
WHI:HMB-IRB	Approved
WHI:HMB-IRB-NPU	Approved

A System for Phenotype Harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

TOPMed data used in this manuscript