A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies
| Submitting Author |
Li, Xihao
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|---|---|
| Submitting Author's Email | |
| Authors |
Xihao Li, Han Chen, Margaret Sunitha Selvaraj, Eric Van Buren, Hufeng Zhou, Yuxuan Wang, Ryan Sun, Zachary R. McCaw, Zhi Yu, Donna K. Arnett, Joshua C. Bis, John Blangero, Eric Boerwinkle, Donald W. Bowden, Jennifer A. Brody, Brian E. Cade, April P. Carson, Jenna C. Carlson, Nathalie Chami, Yii-Der Ida Chen, Joanne E. Curran, Paul S. de Vries, Myriam Fornage, Nora Franceschini, Barry I. Freedman, Charles Gu, Nancy L. Heard-Costa, Jiang He, Lifang Hou, Yi-Jen Hung, Marguerite R. Irvin, Robert C. Kaplan, Sharon L.R. Kardia, Tanika Kelly, Iain Konigsberg, Charles Kooperberg, Brian G. Kral, Changwei Li, Ruth J.F. Loos, Michael C. Mahaney, Lisa W. Martin, Rasika A. Mathias, Ryan L. Minster, Braxton D. Mitchell, May E. Montasser, Alanna C. Morrison, Nicholette D. Palmer, Patricia A. Peyser, Bruce M. Psaty, Laura M. Raffield, Susan Redline, Alexander P. Reiner, Stephen S. Rich, Colleen M. Sitlani, Jennifer A. Smith, Kent D. Taylor, Hemant Tiwari, Ramachandran S. Vasan, Zhe Wang, Lisa R. Yanek, Bing Yu, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Kenneth M. Rice, Jerome I. Rotter, Gina M. Peloso, Pradeep Natarajan, Zilin Li, Zhonghua Liu and Xihong Lin
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| Journal name for most current submission |
Nature Computational Science
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| Associated TOPMed paper proposal | |
| This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" |
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
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| Acknowledgments |
I have followed instructions for TOPMed Acknowledgments
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| I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. |
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
|
| I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. |
Yes
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| I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. |
Yes
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| I certify that all co-authors have reviewed and approved the manuscript for submission. |
Yes
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| Upload all necessary study-specific approval documentation. | |
| I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
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| I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient. |
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
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| I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
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TOPMed data used in this manuscript
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| Parent Study: Consent Group | Review Status |
|---|---|
| ARIC:DS-CVD-IRB | Approved automatically after 2 weeks |
| ARIC:HMB-IRB | Approved automatically after 2 weeks |
| Amish:HMB-IRB-MDS | Approved |
| BioMe:HMB-NPU | Approved |
| CARDIA:HMB-IRB | Approved automatically after 2 weeks |
| CARDIA:HMB-IRB-NPU | Approved automatically after 2 weeks |
| CFS:DS-HLBS-IRB-NPU | Approved automatically after 2 weeks |
| CHS:DS-CVD-MDS | Approved |
| CHS:DS-CVD-NPU-MDS | Approved |
| CHS:HMB-MDS | Approved |
| CHS:HMB-NPU-MDS | Approved |
| DHS:DS-DHD-IRB-COL-NPU | Approved |
| DHS:HMB-IRB-COL-NPU | Approved |
| FHS:HMB-IRB-MDS | Approved automatically after 2 weeks |
| FHS:HMB-IRB-NPU-MDS | Approved automatically after 2 weeks |
| GENOA:DS-ASC-RF-NPU | Approved |
| GOLDN:DS-CVD-IRB | Approved |
| GenSalt:DS-HCR-IRB | Approved automatically after 2 weeks |
| GenSalt:GRU-IRB | Request cancelled by original requester |
| GeneSTAR:DS-CVD-IRB-NPU-MDS | Approved |
| HCHS_SOL:HMB | Approved automatically after 2 weeks |
| HCHS_SOL:HMB-NPU | Approved automatically after 2 weeks |
| HyperGEN:DS-CVD-IRB-RD | Approved |
| HyperGEN:GRU-IRB | Approved |
| JHS:DS-FDO-IRB | Approved |
| JHS:DS-FDO-IRB-NPU | Approved |
| JHS:HMB-IRB | Approved |
| JHS:HMB-IRB-NPU | Approved |
| MESA:HMB | Approved |
| MESA:HMB-NPU | Approved |
| SAFS:DS-DHD-IRB-PUB-MDS-RD | Approved |
| Samoan:GRU-IRB-PUB-COL-NPU-GSO | Approved |
| THRV:DS-CVD-IRB-COL-NPU-RD | Approved automatically after 2 weeks |
| WHI:HMB-IRB | Approved |
| WHI:HMB-IRB-NPU | Approved |
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