Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes
| Submitting Author |
Wessel, Jennifer
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|---|---|
| Submitting Author's Email | |
| Authors |
Jennifer Wessel1,2,3*+, Timothy D Majarian4*, Heather M Highland5, Sridharan Raghavan6,7, Mindy D Szeto8, Natalie R Hasbani9, Paul S de Vries9, Jennifer A Brody10,11, Chloé Sarnowski12, Daniel DiCorpo12, Xianyong Yin13, Bertha Hidalgo14, Xiuqing Guo15, James Perry16,17, Jeffrey R O'Connell16,17, Samantha Lent12, May E Montasser16, Brian E Cade18,19,20, Deepti Jain21, Heming Wang18,19,20, Peitao Wu12, Silvia Bonàs-Guarch22,23, Ricardo D'Oliveira Albanus24, Aaron Leong25,26,27, Irene Miguel-Escalada22,23, Arushi Varshney24, Anubha Mahajan28, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Anthropometry, DIAMANTE, Gregory L Kinney17,29, Lisa R Yanek30, Leslie Lange31, Marcio Almeida32, Juan M Peralta32, Stella Aslibekyan33, Abigail S Baldridge34, Alain G Bertoni35, Lawrence F Bielak36, Donald W Bowden37, Chung-Shiuan Chen38, Yii-Der Ida Chen15, Seung Hoan Choi20, Won Jung Choi39, Dawood Darbar40, James S Floyd41,42, Barry I Freedman43, Mark O Goodarzi44, Ryan Irvin14, Rita R Kalyani30, Tanika Kelly38, Seonwook Lee39, Ching-Ti Liu12, Douglas Loesch45,46,17, JoAnn E Manson26,47, Rami Nassir48, Nicholette D Palmer37, James S Pankow49, Laura J Rasmussen-Torvik34, Alexander P Reiner50, Elizabeth Selvin51, Aladdin H Shadyab52, Jennifer A Smith36,53, Daniel E Weeks54,55, Lu-Chen Weng20,56, Huichun Xu16,17, Jie Yao15, Zachary Yoneda57, Wei Zhao36, Jorge Ferrer22,23,58, Mark I McCarthy28,59, Stephen Parker24,60, Alvaro Alonso61, Donna K Arnett62, John Blangero32, Eric Boerwinkle9, Michael H Cho63, Adolfo Correa64, L. Adrienne Cupples12,65, Joanne E Curran32, Ravindranath Duggirala32, Patrick T Ellinor20,56, Jiang He38, Susan R Heckbert41,50, Sharon LR Kardia36, Ryan W Kim39, Charles Kooperberg66, Simin Liu67, Steven A Lubitz20,56, Rasika A Mathias30, Stephen McGarvey68, Braxton D Mitchell16,17,69, Alanna C Morrison9, Patricia A Peyser36, Bruce M Psaty10,50,11,70, Susan Redline18,19,71, Dan Roden72, M. Benjamin Shoemaker73, Nicholas L Smith50,74,75, Kent D Taylor15, Ramachandran S Vasan65,76,77, Karine A Viaud-Martinez78, Jose C Florez4,20,25,26, James G Wilson79, Robert Sladek80,81, Josée Dupuis12, Stephen S Rich82, Jerome I Rotter15, James B Meigs20,26,27, Alisa K Manning4,26,83+
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| Journal name for most current submission |
Nature
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| Associated TOPMed paper proposal | |
| This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" |
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
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| Acknowledgments |
I have followed instructions for TOPMed Acknowledgments
|
| I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. |
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
|
| I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. |
Yes
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| I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. |
Yes
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| I certify that all co-authors have reviewed and approved the manuscript for submission. |
Yes
|
| Upload all necessary study-specific approval documentation. | |
| I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
|
| I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient. |
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
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| I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
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TOPMed data used in this manuscript
The data set approvals listed here should match the TOPMed data used in this manuscript.
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| Parent Study: Consent Group | Review Status |
|---|---|
| ARIC:DS-CVD-IRB | Approved automatically after 2 weeks |
| ARIC:HMB-IRB | Approved automatically after 2 weeks |
| Amish:HMB-IRB-MDS | Approved |
| CCAF:GRU-IRB | Approved |
| CFS:DS-HLBS-IRB-NPU | Approved |
| CHS:HMB-NPU-MDS | Approved |
| COPDGene:HMB | Approved automatically after 2 weeks |
| DHS:DS-DHD-IRB-COL-NPU | Approved |
| DHS:HMB-IRB-COL-NPU | Approved |
| FHS:HMB-IRB-MDS | Approved automatically after 2 weeks |
| FHS:HMB-IRB-NPU-MDS | Approved automatically after 2 weeks |
| GENOA:DS-ASC-RF-NPU | Approved |
| GOLDN:DS-CVD-IRB | Approved |
| GenSalt:GRU-IRB | Approved automatically after 2 weeks |
| GeneSTAR:DS-CVD-IRB-NPU-MDS | Approved |
| HCHS_SOL:HMB | Request cancelled by original requester |
| HCHS_SOL:HMB-NPU | Request cancelled by original requester |
| HVH:DS-CVD-IRB-MDS | Approved |
| HVH:HMB-IRB-MDS | Approved |
| HyperGEN:DS-CVD-IRB-RD | Approved |
| HyperGEN:GRU-IRB | Approved automatically after 2 weeks |
| JHS:DS-FDO-IRB | Approved |
| JHS:DS-FDO-IRB-NPU | Approved |
| JHS:HMB-IRB | Approved |
| JHS:HMB-IRB-NPU | Approved |
| MESA:HMB | Approved |
| MESA:HMB-NPU | Approved |
| MGH_AF:DS-AF-IRB-RD | Approved automatically after 2 weeks |
| MGH_AF:HMB-IRB | Approved automatically after 2 weeks |
| Partners:HMB | Approved |
| SAFS:DS-DHD-IRB-PUB-MDS-RD | Approved |
| Samoan:GRU-IRB-PUB-COL-NPU-GSO | Approved automatically after 2 weeks |
| THRV:DS-CVD-IRB-COL-NPU-RD | Request cancelled by original requester |
| VAFAR:HMB-IRB | Approved automatically after 2 weeks |
| VU_AF:GRU-IRB | Approved |
| WGHS:HMB | Request cancelled by original requester |
| WHI:HMB-IRB | Approved |
| WHI:HMB-IRB-NPU | Approved |
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