Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

Daniel DiCorpo1,2, Sheila M Gaynor1,3, Emily M Russell4, Kenneth E Westerman5,6,7, Laura M Raffield8, Timothy D Majarian6, Peitao Wu2, Chloé Sarnowski2, Heather M Highland9, Anne Jackson10, TOPMed Diabetes Working Group Banner, Natalie R Hasbani11, Paul S de Vries12, Jennifer A Brody13,14, Bertha Hidalgo15, Xiuqing Guo16, James A Perry17,18, Jeffrey R O'Connell17,18, Samantha Lent2, May E Montasser17, Brian E Cade19,20,21, Deepti Jain22, Heming Wang19,20,21, Ricardo D'Oliveira Albanus23, Arushi Varshney23, Lisa R Yanek24, Leslie Lange25, Nicholette D Palmer26, Marcio Almeida27, Juan M Peralta27, Stella Aslibekyan28, Abigail S Baldridge29, Alain G Bertoni30, Lawrence F Bielak31, Chung-Shiuan Chen32, Yii-Der Ida Chen16, Won Jung Choi33, Mark O Goodarzi34, James S Floyd35,36, Marguerite R Irvin15, Rita R Kalyani24, Tanika Kelly32, Seonwook Lee33, Ching-Ti Liu2, Douglas Loesch37,38,18, JoAnn E Manson7,39, James S Pankow40, Laura J Rasmussen-Torvik29, Alexander P Reiner41, Elizabeth Selvin42, Jennifer A Smith31,43, Daniel E Weeks44,4, Huichun Xu17,18, Jie Yao16, Wei Zhao31, Stephen Parker23,45, Alvaro Alonso46, Donna K Arnett47, John Blangero27, Eric Boerwinkle11, Adolfo Correa48, L. Adrienne Cupples2,49, Joanne E Curran27, Ravindranath Duggirala27, Jiang He32, Susan R Heckbert35,41, Sharon LR Kardia31, Ryan W Kim33, Charles Kooperberg50, Simin Liu51, Rasika A Mathias24, Stephen T McGarvey52, Braxton D Mitchell17,18,53, Alanna C Morrison11, Patricia A Peyser31, Bruce M Psaty13,41,14,54, Susan Redline19,20,55, Alan R Shuldiner56, Kent D Taylor16, Ramachandran S Vasan49,57,58, Karine A Viaud-Martinez59, Jose C Florez6,21,60,7, James G Wilson61, Robert Sladek62,63, Stephen S Rich64, Jerome I Rotter16, Xihong Lin3, Josée Dupuis2, James B Meigs21,7,65, Jennifer Wessel66,67,68, Alisa K Manning6,7,5

1These authors contributed equally to this work, 2Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA, 3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA, 4Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA, 5Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, 02114, USA, 6Metabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA, 7Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA, 8Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA, 9Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA, 10Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA, 11Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA, 12Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA, 13Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA, 14Department of Medicine, University of Washington, Seattle, WA, 98101, USA, 15Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 35294, USA, 16The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA, 17Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA, 18Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA, 19Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA, 20Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA, 21Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA, 22Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA, 23Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA, 24GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA, 25Department of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO, 80045, USA, 26Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA, 27Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA, 2823andMe, Sunnyvale, CA, 94086, USA, 29Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA, 30Department of Epidemiology & Prevention, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA, 31Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA, 32Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA, 33Psomagen, Inc., Rockville, MD, 20850, USA, 34Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA, 35Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA, 36Department of Medicine, University of Washington, Seattle, WA, 98195, USA, 37Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA, 38Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA, 39Brigham and Women's Hospital, Boston, MA, 02115, USA, 40Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA, 41Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA, 42Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21287, USA, 43Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., 44Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA, 45Department of Human Genetics, University of Michigan, MI, 48109, USA, 46Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA, 47College of Public Health, University of Kentucky, Lexington, KY, 40506, USA, 48Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39211, USA, 49National Heart Lung and Blood Institute and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA, 50Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA, 51Center for Global Cardiometabolic Health (CGCH), Boston, MA, 02215, USA, 52International Health Institute and Department of Epidemiology, Brown University School of Public Health, Providence, RI, 02912, USA, 53Geriatrics Research and Education Clinical Center, Baltimore VA Medical Center, Baltimore, MD, 21201, USA, 54Department of Health Services, University of Washington, Seattle, WA, 98101, USA, 55Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA, 56Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21231, USA, 57Evans Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, 02118, USA, 58Evans Department of Medicine, Whitaker Cardiovascular Institute and Cardiology Section, Boston University School of Medicine, Boston, MA, 02118, USA, 59Illumina Laboratory Services, Illumina, Inc., San Diego, CA, 92122, USA, 60Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, 02114, USA, 61Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA, 62Department of Human Genetics, McGill University, Montreal, Quebec, H3A 0G1, CA, 63Department of Medicine, McGill University, Montreal, Quebec, H3A 0G1, CA, 64Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA, 65Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA, 66Department of Epidemiology, Fairbanks School of Public Health, Indiana University, IN, 46202, USA, 67Department of Medicine, School of Medicine, Indiana University, IN, 46202, USA, 68Diabetes Translational Research Center, Indiana University, IN, 46202, USA