Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts

Debby Ngo1,2*, Katherine A. Pratte3*, Claudia Flexeder4*, Hans Petersen5*, Hong Dang6*, Yanlin Ma7*, Michelle J. Keyes1*, Bennet D. Peterson1, Victoria M. Sitar1, Lucas Gillenwater3, Claire Emson8, Christian Gieger4,9, Karsten Surhe10, Johannes Graumann11, Deepti Jain12, Matthew P. Conomos12, Russell P. Tracy13, Xiuqing Guo14, Yongmei Liu15, W. Craig Johnson12, Elaine Cornell13, Peter Durda13, Kent D. Taylor14, George J. Papanicolaou16, Stephen S. Rich7, Jerome I. Rotter14, Steven I. Rennard17, Jeffrey L. Curtis18, Prescott G. Woodruff19, Alejandro Comellas20, Edwin K. Silverman21, James D. Crapo3, Martin G. Larson22,23, Ramachandran S. Vasan23,24, Thomas J. Wang25,26, Robert E. Gerszten1,27, George T. O’Connor23,28, R Graham Barr29, David Couper6, Josee Dupuis22,23, Ani Manichaikul7†, Wanda K. O’Neal6†, Yohannes Tesfaigzi5,30†, Holger Schulz4,31†, Russell P. Bowler3†

*equal contribution as first coauthors, †equal contribution as senior coauthors
1Cardiovascular Research Institute and 2Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3National Jewish Health, Denver, CO, USA; 4Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; 5Lovelace Respiratory Research Institute, Albuquerque, NM, USA; 6University of North Carolina, Chapel Hill, NC, USA; 7Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA; 8Translational Science and Experimental Medicine, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; 9Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; 10Weill Cornell Medicine Qatar, Department of Physiology and Biophysics, Education City, Doha, Qatar; 11Scientific Service Group Biomolecular Mass Spectrometry, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany; 12Department of Biostatistics, University of Washington, Seattle, WA, USA; 13Department of Pathology & Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA; 14The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA; 15Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; 16National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD, USA;17University of Nebraska, Omaha, NE, USA; 18University of Michigan, Ann Arbor, MI, USA; 19 University of California, San Francisco, CA, USA;20 University of Iowa, Iowa City, IA, USA;21 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA; 22Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA;23The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA;24 Department of Medicine, Divisions of Preventive Medicine and Cardiology, Boston University School of Medicine, MA, USA; 25Departments of Medicine and Biomedical Informatics and 26Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;27Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 28Pulmonary Center, Department of Medicine, Boston University, Boston, MA, USA:29Departments of Medicine and Epidemiology, Columbia University, New York, NY, USA;30Brigham and Women’s Hospital, Boston, MA, USA;31Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany