Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program
Manuscript ID: 13371
| Submitting Author |
Manichaikul, Ani
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|---|---|
| Submitting Author's Email | |
| Authors |
Xiaowei Hu1, Dandi Qiao2, Wonji Kim2, Matthew Moll2,3, Pallavi P. Balte4, Leslie A. Lange5, Traci M. Bartz6,7, Rajesh Kumar8, Xingnan Li9, Bing Yu10, Brian E. Cade11,12, Cecelia A. Laurie6, Tamar Sofer11,12, Ingo Ruczinski13, Deborah A. Nickerson14, Donna M. Muzny15, Ginger A. Metcalf15, Harshavardhan Doddapaneni15, Stacy Gabriel16, Namrata Gupta16, Shannon Dugan-Perez15, L. Adrienne Cupples17, Laura R. Loehr18, Deepti Jain6, Jerome I. Rotter19, James G. Wilson20, Bruce M. Psaty21, Myriam Fornage10, Alanna C. Morrison10, Ramachandran S. Vasan22,23, George Washko24, Stephen S. Rich1, George T. O’Connor25, Eugene Bleecker9, Robert C. Kaplan26, Ravi Kalhan27, Susan Redline11,12, Sina A. Gharib28, Deborah Meyers9, Victor Ortega29, Josée Dupuis17, Stephanie J. London30, Tuuli Lappalainen31,32, Elizabeth C. Oelsner4, Edwin K. Silverman2, R Graham Barr4, Timothy A. Thornton6, Heather E. Wheeler33, TOPMed Lung Working Group, Michael H. Cho2, Hae Kyung Im34, Ani Manichaikul1
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| Journal name for most current submission |
American Journal of Human Genetics
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| Associated TOPMed paper proposal | |
| This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" * |
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
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| Acknowledgments |
I have followed instructions for TOPMed Acknowledgments
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| I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. * |
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
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| I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. * |
Yes
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| I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. * |
Yes
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| I certify that all co-authors have reviewed and approved the manuscript for submission. * |
Yes
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| I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
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| I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient. |
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
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| I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
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TOPMed data used in this manuscript
The data set approvals listed here should match the TOPMed data used in this manuscript.
Don't see all the data sets you need? Request more data sets at any time.
Please "cancel" any data set requests that were not used in this manuscript. Note: only the paper proposal submitter or their designated updater can cancel data sets.
| Parent Study: Consent Group | Review Status | Actions |
|---|---|---|
| ARIC:DS-CVD-IRB | Approved automatically after 2 weeks | |
| ARIC:HMB-IRB | Approved automatically after 2 weeks | |
| CARDIA:HMB-IRB | Approved automatically after 2 weeks | |
| CARDIA:HMB-IRB-NPU | Approved automatically after 2 weeks | |
| CFS:DS-HLBS-IRB-NPU | Approved automatically after 2 weeks | |
| CHS:HMB-NPU-MDS | Approved | |
| EOCOPD:DS-CS-RD | Approved | |
| FHS:HMB-IRB-MDS | Approved | |
| FHS:HMB-IRB-NPU-MDS | Approved | |
| HCHS_SOL:HMB | Approved automatically after 2 weeks | |
| HCHS_SOL:HMB-NPU | Approved automatically after 2 weeks | |
| JHS:DS-FDO-IRB | Approved | |
| JHS:DS-FDO-IRB-NPU | Approved | |
| JHS:HMB-IRB | Approved | |
| JHS:HMB-IRB-NPU | Approved | |
| MESA:HMB | Approved | |
| MESA:HMB-NPU | Approved | |
| SPIROMICS:DS-COPD | Approved automatically after 2 weeks | |
| SPIROMICS:DS-COPD-NPU | Approved automatically after 2 weeks | |
| SPIROMICS:GRU | Approved automatically after 2 weeks | |
| SPIROMICS:GRU-NPU | Approved automatically after 2 weeks |
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