Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential
| Submitting Author |
Nakao, Tetsushi
|
|---|---|
| Submitting Author's Email | |
| Authors |
Tetsushi Nakao1,2,3,4, Alexander G. Bick1,5, Margaret A. Taub6, Seyedeh M. Zekavat7, Md M. Uddin1,2, Abhishek Niroula1,3, Cara L. Carty8, John Lane9, Michael C. Honigberg1,2,10, Joshua S. Weinstock11, Akhil Pampana1,2, Christopher J. Gibson10, Gabriel K. Griffin1,12,13, Shoa L. Clarke14, Romit Bhattacharya2,15, Themistocles Assimes14,16, Leslie S. Emery17, Adrienne M. Stilp17, Quenna Wong17, Jai Broome17, Cecelia A. Laurie17, Alyna Khan17, Albert V. Smith11, Thomas W. Blackwell11, Zachary T. Yoneda18, Juan M. Peralta19, Donald W. Bowden20, Marguerite R. Irvin21, Meher Boorgula22, Wei Zhao23, Lisa R. Yanek24, James E. Hixson25, Charles Gu26, Gina M. Peloso27, Dan M. Roden28, Muagututi`a S. Reupena29, Chii-Min Hwu30,31, Dawn L. DeMeo32, Kari E. North33, Shannon Kelly34,35, Solomon K. Musani36, Joshua C. Bis37, Donald M. Lloyd-Jones38,39, Jill M. Johnsen40, Michael Preuss41, Russell P. Tracy42,60, Patricia A. Peyser23, Dandi Qiao32, Pinkal Desai43, Joanne E. Curran19, Barry I. Freedman44, Hemant Tiwari45, Sameer Chavan22, Jennifer A. Smith23,46, Nicholas L. Smith47,48,49, Tanika N. Kelly50,51, Bertha Hildalgo45, L. Adrienne Cupples27,52, Take Naseri53, The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, Ranjan Deka54, Nicola L. Hawley55, Ryan L. Minster56, Daniel E. Weeks57, Lisa de las Fuentes26,58, Laura M. Raffield59, Paul S. Vries25, Alanna C. Morrison25, Christie Ballantyne61, Eimear E. Kenny62,63,64, Stephen S. Rich65, Whitsel A. Eric33,66, Michael H. Cho67, M. Benjamin Shoemaker18, Betty S. Pace68, John Blangero19, Nicholette D. Palmer20, Braxton D. Mitchell69,70, Alan R. Shuldiner71, Kathleen C. Barnes22, Susan Redline10,72,73, Sharon L.R. Kardia23, Abecasis Gonçalo11,74, Lewis C. Becker24, Susan Heckbert47,48, Jiang He50,51, Wendy Post75, Donna K. Arnett76, Ramachandran S. Vasan27,52,77, Dawood Darbar78, Scott T. Weiss10,32, Stephen T. McGarvey79, Mariza de Andrade80, Yii-Der Ida Chen81, Robert C. Kaplan82,83, Deborah A. Meyers84, Brian S. Custer34, Adolfo Correa85, Bruce M. Psaty37,47,86, Myriam Fornage25,87, JoAnn E. Manson10,88,89, Eric Boerwinkle11, Barbara A. Konkle90,91, Ruth J.F. Loos41, Jerome I. Rotter81, Edwin K. Silverman32, Charles Kooperberg92, Siddhartha Jaiswal93, Peter Libby4,10, Patrick T. Ellinor1,94, Nathan Pankratz9, Benjamin L. Ebert1,3,95, Alexander P. Reiner92, Rasika A. Mathias6, Ron Do41,64,96 & Pradeep Natarajan*1,2,10
|
| Journal name for most current submission |
Science Advances
|
| Associated TOPMed paper proposal | |
| This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI" |
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
|
| Acknowledgments |
I have followed instructions for TOPMed Acknowledgments
|
| I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones. |
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
|
| I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable. |
Yes
|
| I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented. |
Yes
|
| I certify that all co-authors have reviewed and approved the manuscript for submission. |
Yes
|
| Upload all necessary study-specific approval documentation. | |
| I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.
|
| I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient. |
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.
|
| I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient. |
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.
|
TOPMed data used in this manuscript
The data set approvals listed here should match the TOPMed data used in this manuscript.
Don't see all the data sets you need? Request more data sets at any time.
Please "cancel" any data set requests that were not used in this manuscript. Note: only the paper proposal submitter or their designated updater can cancel data sets.
| Parent Study: Consent Group | Review Status |
|---|---|
| AFLMU:HMB-IRB-PUB-COL-NPU-MDS | Request cancelled by original requester |
| ARIC:DS-CVD-IRB | Approved automatically after 2 weeks |
| ARIC:HMB-IRB | Approved automatically after 2 weeks |
| Amish:HMB-IRB-MDS | Approved automatically after 2 weeks |
| AustralianFamilialAF:HMB-NPU-MDS | Request cancelled by original requester |
| BAGS:GRU-IRB | Approved |
| BioMe:GRU | Request cancelled by original requester |
| BioMe:HMB-NPU | Approved |
| BioVU_AF:HMB-GSO | Request cancelled by original requester |
| Boston-Brazil_SCD:HMB-IRB-COL | Request cancelled by original requester |
| CAMP:DS-AST-COPD | Request cancelled by original requester |
| CARDIA:HMB-IRB | Approved automatically after 2 weeks |
| CARDIA:HMB-IRB-NPU | Approved automatically after 2 weeks |
| CARE_BADGER:DS-ASTHMA-IRB-COL | Request cancelled by original requester |
| CARE_CLIC:DS-ASTHMA-IRB-COL | Request cancelled by original requester |
| CARE_PACT:DS-ASTHMA-IRB-COL | Request cancelled by original requester |
| CARE_TREXA:DS-ASTHMA-IRB-COL | Request cancelled by original requester |
| CATHGEN:DS-CVD-IRB | Request cancelled by original requester |
| CCAF:GRU-IRB | Request cancelled by original requester |
| CFS:DS-HLBS-IRB-NPU | Approved automatically after 2 weeks |
| CHIRAH:DS-ASTHMA-IRB-COL | Request cancelled by original requester |
| CHS:DS-CVD-MDS | Approved |
| CHS:DS-CVD-NPU-MDS | Approved |
| CHS:HMB-MDS | Approved |
| CHS:HMB-NPU-MDS | Approved |
| COPDGene:DS-CS-RD | Approved |
| COPDGene:HMB | Approved |
| CRA:DS-ASTHMA-IRB-MDS-RD | Approved |
| ChildrensHS_GAP:GRU | Request cancelled by original requester |
| ChildrensHS_IGERA:GRU | Request cancelled by original requester |
| ChildrensHS_MetaAir:GRU | Request cancelled by original requester |
| DECAF:GRU | Request cancelled by original requester |
| DHS:DS-DHD-IRB-COL-NPU | Approved |
| DHS:HMB-IRB-COL-NPU | Approved |
| ECLIPSE:DS-CS-MDS-RD | Approved |
| EGCUT:GRU | Request cancelled by original requester |
| EOCOPD:DS-CS-RD | Approved |
| FHS:HMB-IRB-MDS | Approved automatically after 2 weeks |
| FHS:HMB-IRB-NPU-MDS | Approved automatically after 2 weeks |
| GALAI:DS-LD-IRB-COL | Request cancelled by original requester |
| GALAII:DS-LD-IRB-COL | Request cancelled by original requester |
| GCPD-A:GRU | Request cancelled by original requester |
| GENAF:HMB-NPU | Request cancelled by original requester |
| GENOA:DS-ASC-RF-NPU | Approved |
| GGAF:GRU | Request cancelled by original requester |
| GOLDN:DS-CVD-IRB | Approved |
| GenSalt:DS-HCR-IRB | Approved |
| GenSalt:GRU-IRB | Disapproved |
| GeneSTAR:DS-CVD-IRB-NPU-MDS | Approved |
| HCHS_SOL:HMB | Approved automatically after 2 weeks |
| HCHS_SOL:HMB-NPU | Approved automatically after 2 weeks |
| HVH:DS-CVD-IRB-MDS | Approved automatically after 2 weeks |
| HVH:HMB-IRB-MDS | Approved automatically after 2 weeks |
| HyperGEN:DS-CVD-IRB-RD | Approved |
| HyperGEN:GRU-IRB | Approved |
| INSPIRE_AF:DS-MULTIPLE_DISEASES-MDS | Request cancelled by original requester |
| IPF:DS-ILD-IRB-NPU | Request cancelled by original requester |
| IPF:DS-LD-IRB-NPU | Request cancelled by original requester |
| IPF:DS-PFIB-IRB-NPU | Request cancelled by original requester |
| IPF:DS-PUL-ILD-IRB-NPU | Request cancelled by original requester |
| IPF:HMB-IRB-NPU | Request cancelled by original requester |
| JHS:DS-FDO-IRB | Approved |
| JHS:DS-FDO-IRB-NPU | Approved |
| JHS:HMB-IRB | Approved |
| JHS:HMB-IRB-NPU | Approved |
| JHU_AF:HMB-NPU-MDS | Request cancelled by original requester |
| LTRC:HMB-MDS | Request cancelled by original requester |
| MESA:HMB | Approved |
| MESA:HMB-NPU | Approved |
| MGH_AF:DS-AF-IRB-RD | Request cancelled by original requester |
| MGH_AF:HMB-IRB | Request cancelled by original requester |
| MLOF:HMB-PUB | Approved |
| MPP:HMB-NPU-MDS | Request cancelled by original requester |
| Mayo_VTE:GRU | Approved |
| OMG_SCD:DS-SCD-IRB-PUB-COL-MDS-RD | Request cancelled by original requester |
| PCGC_CHD:DS-CHD | Request cancelled by original requester |
| PCGC_CHD:HMB | Request cancelled by original requester |
| PIMA:DS-ASTHMA-IRB-COL | Request cancelled by original requester |
| PMBB_AF:HMB-IRB-PUB | Request cancelled by original requester |
| PUSH_SCD:DS-SCD-IRB-PUB-COL | Request cancelled by original requester |
| Partners:HMB | Request cancelled by original requester |
| PharmHU:DS-SCD | Approved automatically after 2 weeks |
| PharmHU:DS-SCD-RD | Approved automatically after 2 weeks |
| PharmHU:HMB | Approved automatically after 2 weeks |
| REDS-III_Brazil:GRU-IRB-PUB-COL-NPU | Approved automatically after 2 weeks |
| SAFS:DS-DHD-IRB-PUB-MDS-RD | Approved |
| SAGE:DS-LD-IRB-COL | Request cancelled by original requester |
| SAPPHIRE_asthma:HMB-COL | Request cancelled by original requester |
| SAPPHIRE_asthma:HMB-IRB | Request cancelled by original requester |
| SARP:GRU | Approved automatically after 2 weeks |
| Samoan:GRU-IRB-PUB-COL-NPU-GSO | Approved |
| Sarcoidosis:DS-SAR-IRB | Request cancelled by original requester |
| THRV:DS-CVD-IRB-COL-NPU-RD | Approved automatically after 2 weeks |
| TOPCHeF:GRU-IRB | Request cancelled by original requester |
| VAFAR:HMB-IRB | Approved automatically after 2 weeks |
| VU_AF:GRU-IRB | Approved automatically after 2 weeks |
| WGHS:HMB | Request cancelled by original requester |
| WHI:HMB-IRB | Approved |
| WHI:HMB-IRB-NPU | Approved |
| miRhythm:GRU | Request cancelled by original requester |
| walk_PHaSST:DS-SCD-IRB-PUB-COL-NPU-MDS-RD | Request cancelled by original requester |
| walk_PHaSST:HMB-IRB-PUB-COL-NPU-MDS-GSO | Request cancelled by original requester |
Back to top
