Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

Submitting Author	Willer, Cristen
Submitting Author's Email	cristen@umich.edu
Authors	Jonas B. Nielsen1, Oren Rom1, Ida Surakka1, Sarah E. Graham1, Wei Zhou2,3,4,5*, Lars G. Fritsche1,6,10, Sarah A. Gagliano Taliun6,7, Carlo Sidore8, Yuhao Liu1, Maiken E. Gabrielsen9, Anne Heidi Skogholt9, Brooke Wolford1,6, William Overton6, Whitney E. Hornsby1, Akua Acheampong1, Austen Grooms1, Tanmoy Roychowdhury1, Amanda Schaefer11, Gregory JM Zajac2, Luis Villacorta1, Jifeng Zhang1, Ben Brumpton9,10, Mari Løset9,10, Vivek Rai5, Kent D. Taylor12, Nicholette D. Palmer13, Yii-Der Chen12, Seung Hoan Choi2, Steven A. Lubitz2,14, Patrick T. Ellinor2,14, Kathleen C. Barnes15, Michelle Daya15, Nicholas Rafaels15, Scott T. Weiss16,17, Jessica Lasky-Su16,17, Russell P. Tracy18,19, Ramachandran S. Vasan20,21, L. Adrienne Cupples21,22, Rasika A. Mathias23, Lisa R. Yanek23, Lewis C. Becker23, Patricia A. Peyser24, Lawrence F. Bielak24, Jennifer A. Smith24,25, Stella Aslibekyan26,27, Bertha A. Hildalgo26, Donna K. Arnett28, Marguerite R. Irvin26, James G. Wilson29,30, Solomon K. Musani30,31, Adolfo Correa30,31, Stephen S. Rich32, Xiuqing Guo12, Jerome I. Rotter12, Barbara A. Konkle33, Jill M. Johnsen33, Allison E. Ashley-Koch34,35, Marilyn J. Telen35, Vivien A. Sheehan36, John Blangero37, Joanne E. Curran37, Juan M. Peralta37, Courtney Montgomery38, Wayne H-H Sheu39, Ren-Hua Chung40, Karen Schwander41, Seyed M. Nouraie42, Victor R. Gordeuk43, Yingze Zhang42, Charles Kooperberg44, Alexander P. Reiner44,45, Rebecca D. Jackson46, Eugene R. Bleecker47, Deborah A. Meyers47, Xingnan Li48, Sayantan Das6, Ketian Yu6, Jonathon LeFaive6, Albert Smith6, Tom Blackwell6, Daniel Taliun6, Sebastian Zollner6, Lukas Forer49, Sebastian Schoenherr49, Christian Fuchsberger6,7,50, Anita Pandit6, Matthew Zawistowski6, Sachin Kheterpal51, Chad M. Brummett51, Pradeep Natarajan2,14,52, David Schlessinger53, Seunggeun Lee6, Hyun Min Kang6, Francesco Cucca8,55, Oddgeir L. Holmen9,55, Bjørn O. Åsvold9,55,56, Michael Boehnke6,7, Sekar Kathiresan17,52,57, Goncalo Abecasis6,7,58, Y. Eugene Chen1#, Cristen J. Willer1,5,9,11#, Kristian Hveem9,55#
Journal name for most current submission	Nature Communications
Associated TOPMed paper proposal	Evaluation of LoF variants by PheWAS
This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"	This manuscript has been approved by the original paper proposal's Working Group(s) or is "single PI"
Acknowledgments	I have followed instructions for TOPMed Acknowledgments
I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.	I've received approval for all data sets used in this manuscript, including adding new data sets and canceling all unused ones.
I have followed the Data Use Limitations for each of the data sets used in this manuscript, if applicable.	Yes
I've included at least 1 co-author from each study used in analysis or the PI declined an offer to have their study represented.	Yes
I certify that all co-authors have reviewed and approved the manuscript for submission.	Yes
I've included at least 1 DCC/ACC author, or they declined authorship or deemed acknowledgement sufficient.	I have not
I’ve included at least 1 IRC author, or they declined authorship or deemed acknowledgement sufficient.	I have not
I've included at least 1 author from relevant omics center(s) or they declined authorship or deemed acknowledgement sufficient.	I have not

Parent Study: Consent Group	Review Status